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class=\"wp-block-paragraph\">\u5e74\u8f15\u578b\u5931\u667a\u75c7\u5728\u6574\u500b\u5931\u667a\u75c7\u60a3\u8005\u4e2d\u7684\u6bd4\u4f8b\u76f8\u5c0d\u8f03\u4f4e\uff0c\u4f46\u4ecd\u7136\u5b58\u5728\u4e00\u5b9a\u7684\u7f79\u60a3\u7387\uff0c\u7531\u65bc\u5e74\u8f15\u578b\u5931\u667a\u75c7\u7684\u75c5\u56e0\u8f03\u591a\u6a23\u5316\uff0c\u5177\u9ad4\u7684\u7f79\u60a3\u7387\u6578\u5b57\u53ef\u80fd\u6703\u56e0\u5730\u5340\u3001\u7814\u7a76\u65b9\u6cd5\u548c\u4eba\u53e3\u7d71\u8a08\u8cc7\u6599\u7684\u5dee\u7570\u800c\u6709\u6240\u4e0d\u540c\u3002\u6839\u64da\u4e00\u9805\u767c\u8868\u65bc\u300aThe Lancet Neurology\u300b\u671f\u520a\u7684\u7814\u7a76\uff0c\u4f30\u8a08\u5168\u7403\u5e74\u8f15\u578b\u5931\u667a\u75c7\u7684\u7f79\u60a3\u7387\u7d04\u70ba\u6bcf\u5341\u842c\u4eba\u53e3\u4e2d\u76843.4\u4f8b\uff0c\u9019\u500b\u6578\u5b57\u662f\u6839\u64da\u4e00\u4e9b\u570b\u5bb6\u7684\u6578\u64da\u63a8\u65b7\u800c\u5f97\u51fa\u7684\uff0c\u4e26\u4e14\u53ef\u80fd\u4f4e\u4f30\u4e86\u5be6\u969b\u7684\u7f79\u60a3\u7387\u3002<br><br>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5e74\u8f15\u578b\u5931\u667a\u75c7\u7684\u75c5\u56e0\u548c\u8868\u73fe\u5f62\u5f0f\u5177\u6709\u5f88\u5927\u7684\u5dee\u7570\u6027\uff0c\u5176\u4e2d\u4e00\u4e9b\u75c5\u4f8b\u8207\u57fa\u56e0\u7a81\u8b8a\u6216\u5bb6\u65cf\u6027\u5931\u667a\u75c7\u6709\u95dc\uff0c\u9019\u4e9b\u75c5\u4f8b\u5728\u5e74\u8f15\u4eba\u4e2d\u8f03\u70ba\u5e38\u898b\uff0c\u5176\u4ed6\u7684\u75c5\u56e0\u5247\u53ef\u80fd\u8207\u8166\u90e8\u5275\u50b7\u3001\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3001\u4ee3\u8b1d\u6027\u75be\u75c5\u6216\u611f\u67d3\u7b49\u56e0\u7d20\u6709\u95dc\uff0c\u7531\u65bc\u5e74\u8f15\u578b\u5931\u667a\u75c7\u7684\u7f79\u60a3\u7387\u76f8\u5c0d\u8f03\u4f4e\uff0c\u5c0d\u65bc\u8a72\u75be\u75c5\u7684\u7814\u7a76\u548c\u8a3a\u65b7\u4ecd\u7136\u9762\u81e8\u4e00\u4e9b\u6311\u6230\u3002\u7136\u800c\uff0c\u63d0\u9ad8\u5c0d\u5e74\u8f15\u578b\u5931\u667a\u75c7\u7684\u8a8d\u8b58\u3001\u9032\u884c\u65e9\u671f\u8a3a\u65b7\u548c\u63d0\u4f9b\u9069\u7576\u7684\u652f\u6301\u548c\u8b77\u7406\u5c0d\u65bc\u60a3\u8005\u548c\u4ed6\u5011\u7684\u5bb6\u4eba\u4ecd\u7136\u81f3\u95dc\u91cd\u8981\u3002<br><br>&#8220;Early-onset versus late-onset Alzheimer&#8217;s disease: the case of the missing APOE \u025b4 allele&#8221;\uff0c\u767c\u8868\u65bc\u300aThe Lancet Neurology\u300b\u671f\u520a\uff0c\u78ba\u8a8d\u4e86\u65e9\u767c\u578b\u963f\u8332\u6d77\u9ed8\u75c7\u8207APOE \u025b4\u7b49\u4f4d\u57fa\u56e0\u4e4b\u9593\u7684\u95dc\u806f\u6027\u5dee\u7570\uff0c\u4ed6\u5011\u767c\u73fe\uff0cAPOE \u025b4\u7b49\u4f4d\u57fa\u56e0\u5728\u665a\u767c\u578b\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u4e2d\u7684\u983b\u7387\u660e\u986f\u9ad8\u65bc\u65e9\u767c\u578b\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u9019\u9805\u7814\u7a76\u7684\u7d50\u679c\u8868\u660e\uff0c\u65e9\u767c\u578b\u548c\u665a\u767c\u578b\u963f\u8332\u6d77\u9ed8\u75c7\u53ef\u80fd\u5728\u75c5\u56e0\u5b78\u4e0a\u5b58\u5728\u4e0d\u540c\u7684\u6a5f\u5236\uff0c\u65e9\u767c\u578b\u963f\u8332\u6d77\u9ed8\u75c7\u53ef\u80fd\u8207\u5176\u4ed6\u907a\u50b3\u8b8a\u7570\u6216\u57fa\u56e0\u7a81\u8b8a\u6709\u95dc\uff0c\u800c\u665a\u767c\u578b\u963f\u8332\u6d77\u9ed8\u75c7\u5247\u66f4\u5e38\u8207APOE \u025b4\u7b49\u4f4d\u57fa\u56e0\u76f8\u95dc\uff0c\u9019\u5c0d\u65bc\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u65e9\u671f\u8a3a\u65b7\u3001\u6cbb\u7642\u548c\u9810\u9632\u5177\u6709\u91cd\u8981\u7684\u81e8\u5e8a\u610f\u7fa9\uff0c\u4e26\u70ba\u9032\u4e00\u6b65\u7814\u7a76\u4e0d\u540c\u963f\u8332\u6d77\u9ed8\u75c7\u4e9e\u578b\u7684\u75c5\u56e0\u5b78\u63d0\u4f9b\u4e86\u6709\u50f9\u503c\u7684\u4fe1\u606f\u3002<br><br>&#8220;The role of genetic susceptibility in Alzheimer&#8217;s disease with onset in the presenile period (65 years or younger): an update&#8221;\uff0c\u767c\u8868\u65bc\u300aJournal of Alzheimer&#8217;s Disease\u300b\u671f\u520a\uff0c\u9019\u7bc7\u7814\u7a76\u65e8\u5728\u63a2\u8a0e\u57fa\u56e0\u6613\u611f\u6027\u5728\u65e9\u767c\u6027\u963f\u8332\u6d77\u9ed8\u75c7\uff08\u767c\u75c5\u5e74\u9f61\u572865\u6b72\u6216\u66f4\u5e74\u8f15\uff09\u4e2d\u7684\u89d2\u8272\uff0c\u4e26\u63d0\u4f9b\u6700\u65b0\u7684\u7814\u7a76\u66f4\u65b0\uff0c\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u65e9\u767c\u6027\u963f\u8332\u6d77\u9ed8\u75c7\u8207\u907a\u50b3\u56e0\u7d20\u4e4b\u9593\u5b58\u5728\u8457\u5bc6\u5207\u7684\u95dc\u806f\uff0c\u7279\u5225\u662fAPOE\u57fa\u56e0\u4e2d\u7684\u025b4\u7b49\u4f4d\u57fa\u56e0\u8207\u65e9\u767c\u6027\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u98a8\u96aa\u589e\u52a0\u5bc6\u5207\u76f8\u95dc\uff0c\u7814\u7a76\u9084\u63d0\u5230\u5176\u4ed6\u8207\u65e9\u767c\u6027\u963f\u8332\u6d77\u9ed8\u75c7\u76f8\u95dc\u7684\u57fa\u56e0\u8b8a\u7570\uff0c\u4f8b\u5982PSEN1\u548cPSEN2\u57fa\u56e0\u7684\u7a81\u8b8a\uff0c\u9019\u4e9b\u57fa\u56e0\u7a81\u8b8a\u53ef\u80fd\u5c0e\u81f4\u03b2-\u6dc0\u7c89\u6a23\u86cb\u767d\u7684\u7570\u5e38\u4ee3\u8b1d\uff0c\u9032\u800c\u5c0e\u81f4\u65e9\u767c\u6027\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u767c\u75c5\u3002<br><br>\u9019\u9805\u7814\u7a76\u7684\u7d50\u679c\u5f37\u8abf\u4e86\u65e9\u767c\u6027\u963f\u8332\u6d77\u9ed8\u75c7\u8207\u907a\u50b3\u6613\u611f\u6027\u4e4b\u9593\u7684\u806f\u7e6b\uff0c\u5efa\u8b70\u6c11\u773e\u6709\u76f8\u95dc\u7dca\u8a0a\u61c9\u5118\u901f\u524d\u5f80\u91ab\u7642\u9662\u6240\u6aa2\u67e5\uff0c\u63d0\u65e9\u63a5\u53d7\u9810\u9632\u548c\u6cbb\u7642\u3002<\/p>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5931\u667a\u9810\u9632\u7684\u79d1\u5b78<\/strong><\/p>\n\n\n<p class=\"wp-block-paragraph\">\u200b\u4ee5\u4e0b\u662f\u4e00\u4e9b\u8207\u5931\u667a\u75c7\u9810\u9632\u76f8\u95dc\u7684\u79d1\u5b78\u6587\u737b\uff0c\u60a8\u53ef\u4ee5\u53c3\u8003\u9019\u4e9b\u7814\u7a76\u4f86\u4e86\u89e3\u66f4\u591a\uff1a<br><\/p>\n\n\n<ol class=\"wp-block-list\"><li>Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., &#8230; &#038; Mukadam, N. (2017). Dementia prevention, intervention, and care. The Lancet, 390(10113), 2673-2734.<br><\/li><li>Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K., &#038; Brayne, C. (2014). Potential for primary prevention of Alzheimer&#8217;s disease: an analysis of population-based data. The Lancet Neurology, 13(8), 788-794.<br><\/li><li>Kivipelto, M., Ngandu, T., Laatikainen, T., Winblad, B., Soininen, H., &#038; Tuomilehto, J. (2006). Risk score for the prediction of dementia risk in 20 years among middle-aged people: a longitudinal, population-based study. The Lancet Neurology, 5(9), 735-741.<br><\/li><li>Sabia, S., Fayosse, A., Dumurgier, J., Dugravot, A., Akbaraly, T., Britton, A., &#8230; &#038; Singh-Manoux, A. (2017). Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study. Bmj, 357, j2353.<br><\/li><li>Andrieu, S., Guyonnet, S., Coley, N., Cantet, C., Bonnefoy, M., Bordes, S., &#8230; &#038; Payoux, P. (2017). Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. The Lancet Neurology, 16(5), 377-389.<br><\/li><\/ol>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<\/strong><br><a href=\"https:\/\/ltpa.aistudy.fit\/?pagename=dementia-prevent\">\u6df1\u5165\u4e86\u89e3\u5931\u667a\u75c7: \u4e0d\u540c\u985e\u578b\u7684\u6210\u56e0\u548c\u9810\u9632\u63aa\u65bd<\/a><br><a href=\"https:\/\/ltpa.aistudy.fit\/?pagename=home-training\">\u5931\u667a\u9810\u9632\uff1a\u5c45\u5bb6\u8a8d\u77e5\u8a13\u7df4\u7684\u79d1\u5b78\u65b9\u6cd5<\/a><br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9673\u5b9c\u7537\u8077\u80fd\u6cbb\u7642\u5e2b\uff5c\u63d0\u65e9\u9810\u9632\u6027\u7684\u4ecb\u5165\uff0c\u5ef6\u7de9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-87","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ltpa.aistudy.fit\/index.php\/wp-json\/wp\/v2\/pages\/87","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ltpa.aistudy.fit\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ltpa.aistudy.fit\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ltpa.aistudy.fit\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ltpa.aistudy.fit\/index.php\/wp-json\/wp\/v2\/comments?post=87"}],"version-history":[{"count":0,"href":"https:\/\/ltpa.aistudy.fit\/index.php\/wp-json\/wp\/v2\/pages\/87\/revisions"}],"wp:attachment":[{"href":"https:\/\/ltpa.aistudy.fit\/index.php\/wp-json\/wp\/v2\/media?parent=87"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}